Characteristics of endotoxemia in different ways of treatment of experimental burn in rats

The article evaluates the dynamics of toxemia and detoxification capabilities various wound dressings in thermal burn injury rats experiment. A dressing based on collagen chitosan Collachit® a membrane containing hyperosmolar solution cavity were compared. Studies disease after experimental carried out Wistar (n=20). Analysis results study was basis clinical, morphological biochemical parameters peripheral blood with injury. morphology cells is according to generally accepted methods. Biochemical manifestations endotoxemia are established by ALT, AST, urea, creatinine. In 1st group (n=10), applied. 2nd semi -permeable filled solution, constituting necrolytic enzyme, fixed surface burn. As result, it found that proceeded 2 phases accompanied depression, food refusal, leukocytosis, increased LII, liver transferases, creatinine urea. Hematological deviations characterized non-uniform dynamics, corresponding phase maximum increases days 1-2 5-7, fall 3-4, 8-10. depended method treatment less pronounced use than collachitis. External signs do not all cases correspond hematological profile toxemia, which indicates possibility latent course some methods treatment. applied had antiseptic efficacy, absence purulent-inflammatory complications over entire period